{"id":208,"date":"2021-01-16T11:35:33","date_gmt":"2021-01-16T10:35:33","guid":{"rendered":"https:\/\/orthosportstudio.com\/?page_id=208"},"modified":"2022-02-15T00:00:55","modified_gmt":"2022-02-14T23:00:55","slug":"prp-terapija","status":"publish","type":"page","link":"https:\/\/orthosportstudio.com\/en\/prp-terapija\/","title":{"rendered":"PRP TERAPIJA"},"content":{"rendered":"
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PLATELET-RICH PLASMA AND STEM CELLS<\/h1> <\/div>\n<\/div>\n\t <\/div>\n\t \t<\/div>\n\t\t <\/div>\n\t \n\t<\/div>\n\t\n\t\t\n\t
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Regenerative medicine is a relatively new branch of medicine which emerged with the 21st century, and pertains to the stem cells and their capacity to differentiate into other cells and tissues, thereby opening up great possibilities for the treatment of numerous diseases and injuries. In addition to the stem cells - Bone Marrow Stem Cells (BMSC) and Mesenchymal Stem Cells (MSC), the treatment of diseases and injuries of the osteoarticular system by regenerative medicine entails the use of Platelet-rich plasma (PRP).<\/p>\n

Regenerative medicine is an invaluable option for the treatment of diseases and injuries in cases where many other treatment modalities fail to achieve the desired response.
Li\u010dnim iskustvom koje je bazirano na preko 100 000 aplikacija plazme oboga\u0107ene trombocitima (PRP) personalizovanom metodom, u zavisnosti od simptomatologije pacijenta i klini\u010dkog nalaza, dokazan je ogroman potencijal lije\u010denja ovim terapijskim postupkom.
After two decades of treating patients\u2019 injuries and diseases surgically in his orthopedic practice, Aleksandar Jakovljevi\u0107 MD PhD has been dealing with the methods of regenerative medicine since 2011 with impressive therapeutic results.<\/p>\n

Personal experience based on over 80,000 applications of platelet-rich plasma (PRP) by a customized method, depending on the patient's symptoms and clinical findings, has proven the enormous potential of treatment with this therapeutic procedure.\nThe indications for the use of PRP are numerous, and one of the most common is degenerative knee changes in middle and old age, especially in women. Then, there are degenerative lesions or diseases and injuries of the shoulders, elbows, wrists, hands, spine, hips, ankles, feet, heels, muscles, tendons\u2026
An important task is the treatment of athletes with injuries, as well as the overexertion syndromes. In the case of fresh injuries to muscles, tendons and joints, it is important to initiate the therapy as soon as possible, as it has been proven that methods of regenerative medicine yield the best results if applied within the first 24 hours after the injury.<\/p>\n

Method of Performing the Procedure<\/strong><\/p>\n

The PRP procedure at our clinic involves blood sampling, followed by short-term processing (centrifugation), and application by injection into a painful or injured region. During the application, the patient may feel pain of lesser intensity, which may sometimes last for a couple of hours or a few days after the intervention, which is a normal reaction. Minor hemorrhage may occur at the application spot. The whole procedure takes 20-30 minutes. It is common for a patient to receive 3-5 doses of PRP 5 to 7 days apart.
U okviru na\u0161eg protokola, pristup svakom pacijentu je individualan, a koli\u010dina krvi, broj doza i vremenski interval izme\u0111u doza se odre\u0111uju u zavisnosti od indikacija i simptomatologije, na osnovu klini\u010dke procjene ljekara.
Considering that the patient\u2019s own blood is used, there are no allergic reactions.<\/p>\n

The patients are advised not to take drugs which affect the platelet activity (aspirin, diclofenac, ibuprofen, ketonal, etc.) for a few days before application of the PRP.
The best results are achieved when the application of the PRP is combined with physical treatments.<\/p>\n

Contraindications<\/strong><\/p>\n

PRP se ne primjenjuje kod pacijenata sa malignim bolestima na aktivnom lije\u010denju hemioterapijom, infektivnim febrilnim stanjima, hematolo\u0161kim oboljenjima, dok kod pacijenata koji koriste antikoagulanse ili kortikosteroide odluka o primjeni PRP se donosi individualno.<\/p> <\/div>\n<\/div>\n\t <\/div>\n\t \t<\/div>\n\t\t <\/div>\n\t \n\t<\/div>\n\t\n\t\t\n\t

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STEM CELLS\u00a0<\/strong><\/h1>\n

Stem cells are pluripotent cells with the capacity to self-renew, differentiate and proliferate. They have the ability to develop into any cell and thus build different tissues. They retain this ability throughout their lifetime, i.e., they form a reserve for damaged tissues and organs.<\/p>\n

We must distinguish between 2 models of stem cell treatment. One option is allogeneic transplantation, in which the patient receives stem cells from an appropriate compatible donor - from a relative or from a person with whom he\/she is not related. Another option is autologous transplantation in which the patient receives his own stem cells.<\/p>\n

Stem cells are divided into embryonic stem cells (ESC) and adult stem cells (ASC).<\/p>\n

Embryonic Stem Cells (ESC)\u00a0<\/strong><\/p>\n

Embryonic stem cells represent cell cultures which form after conception. They develop from the epiblast tissue of the inner mass of blastocyst cells. Blastocyst is the early development of an embryo - approximately 4 to 5 days old fetus. Embryonic cells are pluripotent and theoretically may differentiate into cells derived from all three embryonic layers. Therefore, they may develop into any of more than 200 types of adult human body cells when they have sufficient stimulation for a specific cell type. They were first isolated from the inner layer of mouse embryo cells in 1981.<\/p>\n

These cells are only available if the embryo is destroyed in the laboratory, which is completely unethical from a medical as well as from a legal point of view. Hence, although they seem ideal for the processes of regenerative medicine, there are a number of ethical and practical issues which significantly complicate and restrict their application.<\/p>\n

Adult stem cells (ASC)\u00a0<\/strong><\/p>\n

Adultne mati\u010dne \u0107elije su postnatalne \u0107elije, tj.\u00a0 \u0107elije koje nakon ro\u0111enja ostaju u na\u0161em\u00a0 organizmu i u\u010destvuju u procesima reparacije o\u0161te\u0107enog tkiva. One stare kao i sam organizam, pa vremenom\u00a0 gube\u00a0 na\u00a0 vitalnosti. Izoluju se iz\u00a0 organizma nakon ro\u0111enja\u00a0 i\u00a0 imaju\u00a0 manji\u00a0 diferencijalni\u00a0 potencijal, ali puno vi\u0161e\u00a0 prednosti kada se govori o\u00a0 njihovoj primjeni u regenerativnoj medicini.\u00a0 Adultne mati\u010dne \u0107elije se iz\u00a0 organizma dobijaju punkcijom ko\u0161tane sr\u017ei karli\u010dnih kostiju ili drugih dugih kostiju ili masnog tkiva. Dijele se na mati\u010dne\u00a0 \u0107elije ko\u0161tane sr\u017ei – Bone Marrow Stem cells (BMSC) i mati\u010dne \u0107elije masnog tkiva – Adipose mesenchymal stem cells (AMSC).<\/p>\n

Bone marrow stem cells are obtained (BMSC) by penetrating the bone with appropriate equipment, also known as trepanning, then harvesting the bone marrow and processing it according to the protocol. The most common bone marrow aspiration is performed on the pelvic bones or other long bones.<\/p>\n

Obtaining stem cells from adipose tissue (AMSC) is performed by liposuction, and after obtaining the adipose tissue, stem cells are processed and prepared according to the protocol. Adipose tissue is obtained from the region of anterior abdominal wall. The procedure takes place in the operating room, by observing the principles of asepsis and antisepsis.<\/p>\n

The presence of stem cells, as well as the cytokines and other chemical signals they secrete, enables fast and efficient tissue regeneration at the spot of application.<\/p> <\/div>\n<\/div>\n\t <\/div>\n\t \t<\/div>\n\t\t <\/div>\n\t \n\t<\/div>\n\t\n\t\t\n\t

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PLAZMA OBOGA\u0106ENA TROMBOCITIMA I MATI\u010cNE \u0106ELIJE Regenerativna medicina je relativno nova grana medicine kojom je zapo\u010deo 21. vijek, a vezuje se za mati\u010dne \u0107elije i njihovu sposobnost da se diferenciraju u druge \u0107elije i tkiva \u010dime se otvaraju velike mogu\u0107nosti terapije brojnih oboljenja i povreda. Pored mati\u010dnih \u0107elija – Bone Marrow Stem Cells (BMSC) i […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"yoast_head":"\nPLAZMA OBOGA\u0106ENA TROMBOCITIMA I MATI\u010cNE \u0106ELIJE - ORTOPEDSKA SPORTSKA AMBULANTA \u201cORTHOSPORT\u201d<\/title>\n<meta name=\"description\" content=\"Preko 60 000 aplikacija PRP terapije u zadnjih 10 godina stavlja nas me\u0111u lidere u Evropi na polju regenerativne medicine.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/orthosportstudio.com\/en\/prp-terapija\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PLAZMA OBOGA\u0106ENA TROMBOCITIMA I MATI\u010cNE \u0106ELIJE - ORTOPEDSKA SPORTSKA AMBULANTA \u201cORTHOSPORT\u201d\" \/>\n<meta property=\"og:description\" content=\"Preko 60 000 aplikacija PRP terapije u zadnjih 10 godina stavlja nas me\u0111u lidere u Evropi na polju regenerativne medicine.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/orthosportstudio.com\/en\/prp-terapija\/\" \/>\n<meta property=\"og:site_name\" content=\"Orthosport Studio\" \/>\n<meta property=\"article:modified_time\" content=\"2022-02-14T23:00:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/orthosportstudio.com\/wp-content\/uploads\/2021\/01\/DSC_2452@2x-150x150.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/orthosportstudio.com\/en\/prp-terapija\/\",\"url\":\"https:\/\/orthosportstudio.com\/en\/prp-terapija\/\",\"name\":\"PLAZMA OBOGA\u0106ENA TROMBOCITIMA I MATI\u010cNE \u0106ELIJE - 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ORTOPEDSKA SPORTSKA AMBULANTA \u201cORTHOSPORT\u201d","description":"Preko 60 000 aplikacija PRP terapije u zadnjih 10 godina stavlja nas me\u0111u lidere u Evropi na polju regenerativne medicine.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/orthosportstudio.com\/en\/prp-terapija\/","og_locale":"en_US","og_type":"article","og_title":"PLAZMA OBOGA\u0106ENA TROMBOCITIMA I MATI\u010cNE \u0106ELIJE - ORTOPEDSKA SPORTSKA AMBULANTA \u201cORTHOSPORT\u201d","og_description":"Preko 60 000 aplikacija PRP terapije u zadnjih 10 godina stavlja nas me\u0111u lidere u Evropi na polju regenerativne medicine.","og_url":"https:\/\/orthosportstudio.com\/en\/prp-terapija\/","og_site_name":"Orthosport Studio","article_modified_time":"2022-02-14T23:00:55+00:00","og_image":[{"url":"https:\/\/orthosportstudio.com\/wp-content\/uploads\/2021\/01\/DSC_2452@2x-150x150.png"}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/orthosportstudio.com\/en\/prp-terapija\/","url":"https:\/\/orthosportstudio.com\/en\/prp-terapija\/","name":"PLAZMA OBOGA\u0106ENA TROMBOCITIMA I MATI\u010cNE \u0106ELIJE - ORTOPEDSKA SPORTSKA AMBULANTA \u201cORTHOSPORT\u201d","isPartOf":{"@id":"https:\/\/orthosportstudio.com\/en\/#website"},"datePublished":"2021-01-16T10:35:33+00:00","dateModified":"2022-02-14T23:00:55+00:00","description":"Preko 60 000 aplikacija PRP terapije u zadnjih 10 godina stavlja nas me\u0111u lidere u Evropi na polju regenerativne medicine.","breadcrumb":{"@id":"https:\/\/orthosportstudio.com\/en\/prp-terapija\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/orthosportstudio.com\/en\/prp-terapija\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/orthosportstudio.com\/en\/prp-terapija\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/orthosportstudio.com\/en\/"},{"@type":"ListItem","position":2,"name":"PRP TERAPIJA"}]},{"@type":"WebSite","@id":"https:\/\/orthosportstudio.com\/en\/#website","url":"https:\/\/orthosportstudio.com\/en\/","name":"Orthosport Studio","description":"Ortopedska sportska ambulanta","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/orthosportstudio.com\/en\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"}]}},"builder_content":"<h1>PLAZMA OBOGA\u0106ENA TROMBOCITIMA I MATI\u010cNE \u0106ELIJE<\/h1>\n<p style=\"text-align: justify;\">Regenerativna medicina je relativno nova grana medicine kojom je zapo\u010deo 21. vijek, a vezuje se za mati\u010dne \u0107elije i njihovu sposobnost da se diferenciraju u druge \u0107elije i tkiva \u010dime se otvaraju velike mogu\u0107nosti terapije brojnih oboljenja i povreda. Pored mati\u010dnih \u0107elija - Bone Marrow Stem Cells (BMSC) i Mesenchymal Stem Cells (MSC), lije\u010denje oboljenja i povreda ko\u0161tano zglobnog sistema metodama regenerativne medicine, podrazumijeva i primjenu plazme oboga\u0107ene trombocitima \u2013 Platelets rich plasma (PRP).<br \/>Regenerativna medicina predstavlja dragocjenu opciju tretmana oboljenja i povreda u slu\u010dajevima kada se brojnim drugim modalitetima lije\u010denja ne posti\u017ee \u017eeljeni odgovor.<br \/>Primjenom metoda regenerativne medicine mogu\u0107e je odlo\u017eiti potrebu za operativnim zahvatom kod pacijenata kojima je indikovana hirur\u0161ka intervencija. Ove procedure pokre\u0107u mehanizme regeneracije, smanjuju zapaljenske reakcije u zglobovima i tkivima, \u010dime se ubla\u017eava bol i pove\u0107ava pokretljivost, te olak\u0161avaju kretanje.<\/p> <p style=\"text-align: justify;\">Nakon dvije decenije lije\u010denja povreda i oboljenja pacijenata operativnim putem u svojoj ortopedskoj praksi, prof.dr Aleksandar Jakovljevi\u0107 od 2011. godine bavi se metodama regenerativne medicine uz impresivne terapijske rezultate.<br \/>Li\u010dnim iskustvom koje je bazirano na preko 100 000 aplikacija plazme oboga\u0107ene trombocitima (PRP) personalizovanom metodom, u zavisnosti od simptomatologije pacijenta i klini\u010dkog nalaza, dokazan je ogroman potencijal lije\u010denja ovim terapijskim postupkom.<br \/>Indikacije za primjenu PRP su brojne, a jedna od naj\u010de\u0161\u0107ih su degenerativne promjene koljena u srednjoj i starijoj \u017eivotnoj dobi, posebno kod \u017eena. Potom, degenerativne lezije ili oboljenja i povrede ramena, lakta, ru\u010dnog zgloba, \u0161ake, ki\u010dme, kukova, sko\u010dnih zglobova, stopala, peta, mi\u0161i\u0107a, tetiva\u2026<\/p> <p style=\"text-align: justify;\">Va\u017ean zadatak predstavlja tretman sportista sa povredama, kao i sindromi prenaprezanja\u2026<br \/>U slu\u010daju svje\u017eih povreda mi\u0161i\u0107a, tetiva i zglobova, bitno je da se terapija po\u010dne \u0161to prije, jer je dokazano da metode regenerativne medicine daju najbolje rezultate ako se primijene u prvih 24 sata nakon povrede.<\/p> <p><strong>Na\u010din izvo\u0111enja procedure<\/strong><\/p> <p style=\"text-align: justify;\">U na\u0161oj ordinaciji procedura PRP podrazumijeva va\u0111enje krvi, potom slijedi kratkotrajna obrada (centrifugiranje), te aplikacija putem injekcije u bolnu ili povrije\u0111enu regiju. Pri aplikaciji se osjeti bol slabijeg intenziteta, koji ponekad mo\u017ee potrajati par sati ili par dana nakon intervencije, \u0161to predstavlja normalnu reakciju. Na mjestu primjene mo\u017ee do\u0107i do pojave manjeg krvnog podliva. Cijela procedura traje 20 \u2013 30 min. Uobi\u010dajeno je da pacijent primi 3 \u2013 5 doza PRP u razmaku od 5 do 7 dana.<br \/>U okviru na\u0161eg protokola, pristup svakom pacijentu je individualan, a koli\u010dina krvi, broj doza i vremenski interval izme\u0111u doza se odre\u0111uju u zavisnosti od indikacija i simptomatologije, na osnovu klini\u010dke procjene ljekara.<br \/>S obzirom na to da se radi o vlastitoj krvi, nema alergijskih reakcija.<\/p> <p style=\"text-align: justify;\">Savjetuje se da pacijent nekoliko dana prije aplikacije PRP ne uzima lijekove koji uti\u010du na aktivnost trombocita (aspirin, diklofenak, brufen, ketonal..).<br \/>Najbolji rezultati se posti\u017eu kada se primjena PRP kombinuje sa fizikalnim tretmanima.<\/p> <p><strong>Kontraindikacije<\/strong><\/p> <p style=\"text-align: justify;\">PRP se ne primjenjuje kod pacijenata sa malignim bolestima na aktivnom lije\u010denju hemioterapijom, infektivnim febrilnim stanjima, hematolo\u0161kim oboljenjima, dok kod pacijenata koji koriste antikoagulanse ili kortikosteroide odluka o primjeni PRP se donosi individualno.<\/p>\n<h1 style=\"text-align: center;\"><strong>MATI\u010cNE \u0106ELIJE\u00a0<\/strong><\/h1> <p>Mati\u010dne \u0107elije su pluripotentne \u0107elije koje imaju sposobnost samoobnavljanja, diferencijacije i proliferacije. One imaju sposobnost da se razviju u bilo koju \u0107eliju i tako grade razli\u010dita tkiva. Tu sposobnost zadr\u017eavaju tokom \u010ditavog \u017eivota, odnosno \u010dine rezervu za o\u0161te\u0107ena tkiva i organe.<\/p> <p style=\"text-align: left;\">Neophodno je napraviti razliku izme\u0111u 2 modela tretmana mati\u010dnim\u00a0 \u0107elijama. Jedna opcija je alogena transplantacija\u00a0 \u2013\u00a0 u kojoj pacijent prima mati\u010dne \u0107elije od odgovaraju\u0107eg kompatibilnog donora - od ro\u0111aka ili od osobe sa kojom nije u krvnom srodstvu. Druga opcija je autologna transplantacija u kojoj pacijent prima vlastite mati\u010dne \u0107elije.<\/p> <p style=\"text-align: left;\">Osnovna podjela mati\u010dnih \u0107elija je na embrionalne mati\u010dne \u0107elije (ESC) i adultne mati\u010dne\u00a0 \u0107elije (ASC).<\/p> <p style=\"text-align: left;\"><strong>Embrionalne mati\u010dne \u0107elije \u2013 embryonic stem cells (ESC)\u00a0<\/strong><\/p> <p style=\"text-align: left;\">Embrionalne mati\u010dne \u0107elije predstavljaju\u00a0 kulture \u0107elija koje nastaju nakon za\u010de\u0107a. Razvijaju\u00a0 se od ebiplastnog tkiva unutra\u0161nje mase \u0107elija blastocista. Blastocista je rani razvoj embriona\u00a0 \u2013 otprilike 4 do 5 dana starog fetusa. Embrionalne \u0107elije su pluripotentne, te teoretski se mogu\u00a0 diferencirati u \u0107elije koje poti\u010du od sva tri embrionalna lista. Dakle, mogu se razviti u svaku\u00a0 od\u00a0 vi\u0161e\u00a0 od\u00a0 200\u00a0 tipova\u00a0 \u0107elija\u00a0 odraslog\u00a0 tijela\u00a0 \u010dovjeka\u00a0 kada\u00a0 imaju\u00a0 dovoljnu\u00a0 stimulaciju\u00a0 za\u00a0 specifi\u010dan tip \u0107elija.. Prvi put su izolovane iz unutra\u0161njeg sloja \u0107elija mi\u0161jeg embriona 1981.<\/p> <p style=\"text-align: left;\">Ove \u0107elije su jedino dostupne ukoliko se embrion razori u laboratorijskim uslovima, \u0161to je\u00a0 potpuno neeti\u010dno sa medicinskog, kao i sa pravnog stanovi\u0161ta. Dakle, iako se \u010dine kao idealne\u00a0 za procese regenerativne medicine, postoji \u010ditav niz eti\u010dkih i prakti\u010dnih problema koji zna\u010dajno\u00a0 ote\u017eavaju i ograni\u010davaju njihovu primjenu.<\/p> <p style=\"text-align: left;\"><strong>Adultne (zrele) mati\u010dne \u0107elije \u2013 adult stem cells (ASC)\u00a0<\/strong><\/p> <p style=\"text-align: left;\">Adultne mati\u010dne \u0107elije su postnatalne \u0107elije, tj.\u00a0 \u0107elije koje nakon ro\u0111enja ostaju u na\u0161em\u00a0 organizmu i u\u010destvuju u procesima reparacije o\u0161te\u0107enog tkiva. One stare kao i sam organizam, pa vremenom\u00a0 gube\u00a0 na\u00a0 vitalnosti. Izoluju se iz\u00a0 organizma nakon ro\u0111enja\u00a0 i\u00a0 imaju\u00a0 manji\u00a0 diferencijalni\u00a0 potencijal, ali puno vi\u0161e\u00a0 prednosti kada se govori o\u00a0 njihovoj primjeni u regenerativnoj medicini.\u00a0 Adultne mati\u010dne \u0107elije se iz\u00a0 organizma dobijaju punkcijom ko\u0161tane sr\u017ei karli\u010dnih kostiju ili drugih dugih kostiju ili masnog tkiva. Dijele se na mati\u010dne\u00a0 \u0107elije ko\u0161tane sr\u017ei - Bone Marrow Stem cells (BMSC) i mati\u010dne \u0107elije masnog tkiva - Adipose mesenchymal stem cells (AMSC).<\/p> <p style=\"text-align: left;\">Dobijanje mati\u010dnih \u0107elija\u00a0 iz\u00a0 ko\u0161tane\u00a0 sr\u017ei\u00a0 (BMSC) radi se\u00a0 na taj na\u010din\u00a0 da se putem odgovaraju\u0107e opreme vr\u0161i otvaranje kost \u2013 trepanacija, uzimanje ko\u0161tane sr\u017ei, te njena obrada\u00a0 prema protokolu. Naj\u010de\u0161\u0107e se vr\u0161i punkcija kostiju karlice, ili drugih dugih kostiju.<\/p> <p style=\"text-align: left;\">Dobijanje mati\u010dnih \u0107elija iz masnog tkiva (AMSC)\u00a0 radi\u00a0 se\u00a0 metodom liposukcije, te nakon\u00a0 dobijanja masnog tkiva vr\u0161i\u00a0 se\u00a0 obrada i priprema mati\u010dnih\u00a0 \u0107elija prema protokolu. Masno tkivo se dobija iz predjela prednjeg trbu\u0161nog zida. Postupak se odvija u operacionoj sali po\u0161tuju\u0107i sve principe asepse i antisepse.<\/p> <p style=\"text-align: left;\">Prisustvo samih mati\u010dnih \u0107elija, kao i citokina i drugih hemijskih signala koje one lu\u010de\u00a0 omogu\u0107ava brzu i efikasnu regeneraciju tkiva na mjestu aplikacije.<\/p>\n[gallery ids=\"247,248\"]","_links":{"self":[{"href":"https:\/\/orthosportstudio.com\/en\/wp-json\/wp\/v2\/pages\/208"}],"collection":[{"href":"https:\/\/orthosportstudio.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/orthosportstudio.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/orthosportstudio.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/orthosportstudio.com\/en\/wp-json\/wp\/v2\/comments?post=208"}],"version-history":[{"count":3,"href":"https:\/\/orthosportstudio.com\/en\/wp-json\/wp\/v2\/pages\/208\/revisions"}],"predecessor-version":[{"id":867,"href":"https:\/\/orthosportstudio.com\/en\/wp-json\/wp\/v2\/pages\/208\/revisions\/867"}],"wp:attachment":[{"href":"https:\/\/orthosportstudio.com\/en\/wp-json\/wp\/v2\/media?parent=208"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}